Abstract
A rapid, sensitive and reliable LC–MS–MS method for the determination of eight benzimidazoles in animal feed was developed and validated. Samples were extracted with acidic acetonitrile. The extract was diluted with 0.1% formic acid in water, and analyzed by LC–MS–MS on a Waters XBridge™ C18 column with acetonitrile/0.1% formic acid in water as mobile phase. The samples were quantified with the matrix standard calibration curve method. Good linearity was obtained for eight benzimidazoles at a concentration of 0.005–2.5 μg mL−1 with a linear relative coefficient more than 0.990. Recoveries of 84.0–104.0% with CVs of 2.50–7.50% were obtained. Limit of detection was 2.1–63.0 μg kg−1. The method demonstrated to be suitable for the determination of eight benzimidazoles in animal feed samples.
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