Abstract
We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device. The system operation was tested with fluorescent plastic micro-bead solutions ranging from 100 beads/μL to 500 beads/μL. We demonstrated that this hybrid lab-on-a-chip fabrication technology is suitable for producing low-cost and portable biological microsystems and for effectively bridging the gap between new device concepts and their mass production.
Highlights
The concept of a lab-on-a-chip (LOC) is founded on the integration of several laboratory functions on a single device with dimensions on the scale of millimeters to few centimeters [1,2]
We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding
To demonstrate the potential of this technology, we introduce a cost-effective and highly portable poly(methyl methacrylate) (PMMA) prototype that is interfaced with a mobile phone to implement an optofluidic cytometry platform
Summary
The concept of a lab-on-a-chip (LOC) is founded on the integration of several laboratory functions on a single device with dimensions on the scale of millimeters to few centimeters [1,2]. Abstract: We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device.
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