Abstract
Rapid Onset of Nucleolar Segregation Followed by DNA Fragmentation in Roscovitine-Treated MCF-7 Cells Supports Its Pro-Apoptotic Potential.
Highlights
Nucleolus, previously thought to be solely involved in synthesis of ribosomes, is reconsidered to be a plurifunctional organelle regulating cellular lifespan and signaling pathways of the programmed cell death (PCD)
We studied morphological changes of nucleoli in roscovitine-treated MCF-7 cells and compared these data with TUNEL staining
Untreated cells contained intact nucleoli in comparison with roscovitine-treated cells (6, 12 and 24 hours), where small nucleolar fragments scattered across the whole nucleus were found
Summary
Previously thought to be solely involved in synthesis of ribosomes, is reconsidered to be a plurifunctional organelle regulating cellular lifespan and signaling pathways of the programmed cell death (PCD).
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