Rapid Method for the Quantitative Measurement of Numerous Pharmaceutically Important Amines

Abstract

Abstract A simplified variation of the bromothymol blue method has been used successfully to analyze numerous pharmaceutically important amines. A single benzene extraction of the yellow amine-dye complex is made possible by buffering the dye solution at pH 7.0 and by maintaining the organic-to-aqueous ratio at not less than 3:1. This procedure not only greatly reduces the analysis time but also makes possible the analysis of numerous aromatic amines by a simple single extractiondye method. Any variation in t h e solubility of the amine-dye complex is compensated for by the simultaneous determ ination of a known standard of equal volume. Total analysis time for a dissolved sample does not exceed 15 min. These factors make the method especially useful for the routine analysis of pharmaceutical products.