Abstract
Poly(propylene glycol) (PPG)-grafted dextran was synthesized by conjugating amino-terminated PPG with hydroxyl groups of dextran, and its inclusion complexation property was investigated. The average number of grafted PPG per dextran was changeable in the range of 1.1 to 38.5. The formation of inclusion complexes between the PPG grafts and β-cyclodextrins (β-CDs) and their crystalline structures were characterized by 13 C CP/MAS NMR and X-ray spectroscopies. These hydrogel systems showed a thermall reversible sol-gel transition based on supramolecular assembly and dissociation between host and guest moieties. The results of theological measurements and solgel transition temperature of the hydrogels suggested that the aggregate channel-type crystalline domain was critical to control the transition temperature in terms of initial feed molar ratio of PPG and β-CD and the graft number of PPG constituents. These thermoreversible hydrogel systems showed rapid gelation properties, which may be useful for biomedical application, especially injectable drug deliver systems.
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