Rapid Increasing Trend of Hepatocellular Carcinoma in Elderly in Japan

Abstract

Purpose: Surgical resection is the gold standard in the treatment for liver metastases of colorectal cancer. In several centers, resection is being replaced by radiofrequency ablation (RFA). The aim of this study was to evaluate the effectiveness of RFA. Methods: We performed RFA in 888 patients from April 2006 to December 2009 at Kanto Medical Center NTT EC. It contained 171(the total number) of liver metastases of colorectal cancer. Median survival time (MST) was determined using Kaplan-Meier curve. The number of lesions and maximum lesion size were assessed. The survival was evaluated, compared with those of systemic S-596 AGA Abstracts chemotherapy in literature. Results: We performed percutaneous RFA in 89 patients (the actual number). All patients underwent resection of primary colorectal cancer. The Median age was 63.5 years-old (38-87) and 71% were male. The Median tumor numbers were 3 (1-34) and median tumor size was 28mm (7-156). 74 patients were performed chemotherapy before ablation. MST of all patients was 25.1 months. One year survival rate from the initial ablation was 82.2% and 2-year was 50.4%. 46 patients had progressive disease (PD) at the chemotherapy before ablation. 13 patients of 46 were performed ablation for partial cure, and these MST was 27.0 months. 8 patients of the 46 were performed ablation for mass reduction therapy, and these MST was 19.6 months. Conclusion: In literature, the MST of the systemic chemotherapy (FOLFOX/XEROX + Bevacizumab) was 21.3 months. Compared with this, MST of this study was longer. So we think performing RFA to liver metastasis might improve the prognosis.