Abstract
A rapid GLC procedure for the precise estimation of salicylic acid in codeine- and propoxyphene-type capsule and tablet analgesic formulations is presented. The sample material is treated with diazomethane prepared in tetrahydrofuran solution, and the salicylic acid is eluted as its methyl ester. Methyl o-methoxybenzoate serves as the internal standard. Peak areas are quantitated by means of an electronic digital integrator of wide input signal range capacity. The results obtained by applying the method to the analysis of 25 commercial preparations were in excellent agreement with those given by the trap column spectrophotometric procedure, except at salicylic acid levels exceeding about 15%. The proposed GLC technique precludes some drawbacks of the column method and is superior in many respects.
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