Rapid generation of molecular complexity using ‘sequenced’ multi-component reactions: one-pot synthesis of 5,5′-disubstituted hydantoins from methyleneaziridines

Abstract

2-Methyleneaziridines can be transformed into 5,5′-disubstituted hydantoins in moderate to good yield (48–75%) via a ‘one-pot’ process that brings together up to six components in an orchestrated way.