Abstract
Massive doses of 35S-labeled disulfide derivatives of thiamine and 35S-labeled thiamine-HCl were administered to rats, and a comparative study was made of the formation of phosphorylated thiamine in the heart and liver by means of starch block electrophoretic techniques. It was noted that thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide, when compared with thiamine-HCl, transferred far more rapidly into heart muscle cells and subsequently were converted into thiamine phosphates. It was also shown that the thiamine triphosphate fraction in the extract of heart tissues showed higher amounts of radioactivity than the thiamine diphosphate fraction. It was conjectured that thiamine triphosphate might play an important role in the contraction processes of the heart.
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