Abstract
In this study, for the first time, a magnetic ionic liquid-based aqueous biphasic system (MIL-ABS) was developed to extract total flavonoids from crude extracts of yam (Dioscorea alata L.) peel. The effect of various conditions on the separation behavior was systematically examined and optimized. A relatively high extraction efficiency (96.4%) and partition coefficient (K = 33.2) for total flavonoids could be achieved. MI-ABS not only has the advantage of being able to extract quickly in the absence of an organic solvent, but it also responds to a simple external magnetic field. This work has the potential to be a useful reference for practical enrichment or separation of active ingredients.
Highlights
ionic liquid (IL)-based aqueous biphasic system (ABS) has been successfully employed for the effective separation/extraction of many bioactive compounds and drugs
T1hne2oObH-]Br in e of this study provided an alternative methodmfoirxitnuvreestiwgaatisngreacttaeidneadtpr5o0douCct wfoars w2a4shhedfowliltohwaceedtonbeyunfitilltrnaotpiorenc.ipTithateioonbtained the flavonoids separation procedure. washed with acetaonndedurinedtilunndoerpvraeccuiupmitaattio5n0oCan. dThderfiiendalupnroddeurcvtsawcueruem at 50o dark-reddish viscous liquids
The band at 1264 cm is assigned to the stretching and partition coefficient until the extraction system becomes espondsvtiobrCat-ioHn aabssyomrpmtioentroicf thine-Cp-lNanbeonbde.nIndiandgdivtiiobnr,a1t0i9o5n.cmT-h1e absastourraptteido.nItbisawndell known that the larger amount of MIL was m-1 is mcaoinrrleyspaosnsdisgtnoetdhetostrtehtcehsinygmvmiberattriiocnionf-Npl-aOnien btheenadninongicvibraadtidoend,othfethmeoCre-MIL-phase volume, which suggested that n the gemstr-udcitmuree.thTyhle opfeatkheata9n7i2oncm(-N1 bieeloent gasl.to2t0h1e7a)s.yTmhmeetbriacnd amto1re26fl4avocnmo-i1dsiswere transmitted into the MIL-rich phase. to the strsetrtecthchininggvviibbrraattiioonnoafbOs-oSr-pOtiionnthoefatnhieonC. -N bond
Summary
Yam is one of the major food crops cultivated in many tropical and subtropical countries (Hu et al 2018, Yeh et al 2013). IL-based ABS has been successfully employed for the effective separation/extraction of many bioactive compounds and drugs Due to the small density difference, IL-based ABS still suffer from inefficient phase The cholinium-based magnetic ionic liquids (MILs) were separation (Yao & Yao 2017). Magnetic ionic liquid (MIL) has recently emerged Briefly, two intermediates were prepared first They were the as a new research focus in the separation/extraction fields alkyl-(2-hydroxyethyl)-dimethylammonium bromide ([N1 1 n (Trujillo-Rodriguez et al 2017, Wang et al 2014, Zhou et 2OH]Br, n= 3, 4, 5, 6) and sodium 4-sulfonatooxy-2,2,6,6-teal. N,N-dimethylethanolamine (0.2 mol) was dissolved in 30 mL a MIL-ABS system based on guanidinium ionic liquid to ethanol, and n-alkyl bromide (0.22 mol) was slowly adddetect trace amounts of chloramphenicol in a water sample.
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