Rapid Estimation of Blood Glucose

Abstract

<b>Introduction:</b> The association of sleep quality with clinical outcomes during the COVID-19 pandemic has not yet been investigated in the asthmatic population. <b>Aims:</b> To verify the correlation of sleep quality with asthma control, quality of life and limitations in activities of daily living (ADL) during the COVID-19 pandemic in adults with asthma. <b>Methods:</b> Sleep quality was objectively measured in adults with asthma by an activity monitor (Actiwatch 2) for 7 consecutive days, during October 2020 to January 2021. Body mass index (BMI), Asthma Control Questionnaire (ACQ), modified Medical Research Council (mMRC), London Chest Activity of Daily Living (LCADL) scale, Saint George’s Respiratory Questionnaire (SGRQ) and Asthma Quality of Life Questionnaire (AQLQ), were also evaluated. Association analysis were performed. <b>Results:</b> Twenty-one adults with asthma (33% males; 54±14 years) were studied. Longer wake after sleep onset time was associated with a worse asthma control assessed by the ACQ (r=0.60; <i>P</i>=0.004); more severe dyspnea by the mMRC (r=0.57; <i>P</i>=0.007); more pronounced limitation in ADL by the LCADL (r=0.50; <i>P</i>=0.021); worse health status by the SGRQ (r=0.50; <i>P</i>=0.021); and worse quality of life by the AQLQ (r=-0.48; <i>P</i>=0.045). The increase in number of awakenings was also correlated with higher BMI (r= 0.56; <i>P</i>= 0.009); worse ACQ (r=0.54; <i>P</i>=0.011), worse mMRC score (r=0.50; <i>P</i>=0.022); worse LCADL (r=0.49; <i>P</i>=0.023); worse SGRQ (r=0.47; <i>P</i>=0.032); and worse AQLQ (r=-0.46; <i>P</i>=0.053). <b>Conclusions:</b> These results suggest that poor quality of sleep is associated with worsening of clinical aspects of asthma, which could generate additional disease burden and worse quality of life.