Abstract
Mink cell focus forming (MCF) virus was always detected in the enlarged spleens of NFS, BALB/c, SL, and C 3H mice infected with NB-tropic ecotropic Friend virus. The MCF virus emerged from the spleens as early as 7 days postinfection. The MCF viruses isolated from various mouse strains were NB-tropic dualtropic and highly oncogenic to newborn NFS and BALB/c mice. When cells infected with MCF virus were overlaid with XC cells without uv irradiation, the viruses were XC positive. Interference and host-range properties suggested that the MCF viruses were recombinants between exogenous NB-tropic ecotropic Friend virus and endogenous xenotropic virus.
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