Rapid disintegrating tablets: an effective method for accelerating the therapeutic action of poorly soluble Drugs

Abstract

The ease of administration and increased patient compliance are critical factors in the design of oral drug delivery systems, which continue to be the dominant method of drug delivery despite numerous shortcomings. The rapid disintegrating tablet (RDT) could be a great alternative to traditional tablets because it dissolves quickly when it comes into contact with saliva. Rapid disintegrating tablets (RDTs) are currently more widely available than other tablets to treat various disorders. Due to its ease of manufacture and administration, oral administration is being investigated as the most frequently used route. Due to its rapid disintegration features, water-free use, and simplicity of swallowing, RDTs, particularly for pediatric patients, are effective drug delivery devices. Rapid disintegrating tablets are solid dosage forms that disintegrate in the mouth without water in less than 60 seconds. Rapid disintegration of tablets results in rapid dissolution and, thus, immediate action. The primary objective of this review paper is to discuss the benefits, drawbacks, formulation issues, manufacturing methods, patented technology and evaluation tests. Spray drying, freeze drying, direct compression, moulding, and sublimation are all traditional ways of preparation, however new technologies have been created for the production of RDTs.
 Keywords: Rapid disintegrating tablets, patient compliance, spray drying, freeze drying, direct compression.