Abstract

Aims: to provide a scientific and practical justification for the use of Raman fluorescence spectroscopy in the early express-diagnostics of laryngeal cancer. Patients and methods. A total of 83 patients with a diagnosis of laryngeal cancer were examined. The spectra of the intact mucous membrane of the larynx, the anatomical structures of the larynx in cancer and precancer were analyzed. The individual features of the bands of Raman scattering of light and fluorescent signals in intact tissues, in case of dysplasia, and squamous cell carcinoma of the larynx were evaluated. To compare the data of Raman fluorescence spectroscopy, the histological method was used in this study. The study evaluated the sensitivity and specificity of the method. To take the spectra, a laser setup was used using both fluorescent and Raman components, with a wavelength of 532 nm. Measurements were taken immediately after removal of the laryngeal tissue (1-5 seconds) involved in the malignant process. Results. In this study, using Raman fluorescence spectroscopy, individual spectral characteristics of the tissues of the larynx were obtained in intact tissues and in laryngeal cancer, as well as in dysplasia (precancer). In this study, in the above groups there are differences both in fluorescence signals and in Raman scattering bands. This information can be useful in the early diagnosis of laryngeal cancer for the clinicians. Conclusions. In the future, Raman fluorescent medical technologies can be used for the purpose of early express diagnostics of tumor diseases of the larynx. Clinical Medicine and Public Health and Healthcare in general need the development of technologies of this kind in order to improve the quality and efficiency of diagnosing and treating diseases at the stage of their initiation.

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