Abstract
Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins' biological functions. During the last decade, proteomics in China has grown much faster than other research fields in the life sciences. At the beginning of the second decade of the 21(st) century, the rapid development of high-resolution and high-speed mass spectrometry makes proteomics a powerful tool to study the mechanisms underlying physiological/pathological processes in organisms. This article provides a brief overview of proteomics technology development and representative scientific progress of the Human Liver Proteome Project (HLPP) in China over the past three years.
Highlights
Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’ biological functions
Proteomics investigation in China has been paced over 10 years under the guidance of the China Human Proteome Organization (CNHUPO), which was formally established in 2003
Protein-protein interaction (PPI) profiling contributes to elucidate protein functions, metabolism and signaling pathways, molecular machines, and functional protein modules, which are one of the major goals of the Human Liver Proteome Project (HLPP) plan
Summary
He FuChu and colleagues in CNHUPO designed and advocated one road map for HLPP and HPP (Human Proteome Project) studies (i.e., two profiles: expression and modification; two maps: interaction and localization; three repositories: sample, antibody and data; and two outputs: physiology and pathology), which had been presented as early as the first HUPO Workshop for Human Proteome Initiatives (Bethesda, MD, USA, April 2002) and were included in the HLPP [5]. Chinese proteomists have made great progress in the last three years (Figure 1)
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