Rapid Development of Multiple Pseudoaneurysms After Arterial Homograft Placement

Abstract

HomeCirculationVol. 114, No. 5Rapid Development of Multiple Pseudoaneurysms After Arterial Homograft Placement Free AccessReview ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessReview ArticlePDF/EPUBRapid Development of Multiple Pseudoaneurysms After Arterial Homograft Placement Michael Heise, MD, Michael Werk, MD, Inga Husmann, MD, Robert Eisele, MD and Peter Neuhaus, MD Michael HeiseMichael Heise From Charité, University Medicine, Department of General Surgery, Berlin, Germany. Search for more papers by this author , Michael WerkMichael Werk From Charité, University Medicine, Department of General Surgery, Berlin, Germany. Search for more papers by this author , Inga HusmannInga Husmann From Charité, University Medicine, Department of General Surgery, Berlin, Germany. Search for more papers by this author , Robert EiseleRobert Eisele From Charité, University Medicine, Department of General Surgery, Berlin, Germany. Search for more papers by this author and Peter NeuhausPeter Neuhaus From Charité, University Medicine, Department of General Surgery, Berlin, Germany. Search for more papers by this author Originally published1 Aug 2006https://doi.org/10.1161/CIRCULATIONAHA.105.605436Circulation. 2006;114:e80–e81A 52-year-old woman received a preserved aorto-bifemoral homograft to treat an infection of an aorto-bifemoral Dacron graft (Vascutek, Renfrewshire, Scotland) that was implanted 5 years ago. The infected graft was completely removed during the operation. Donor and recipient blood groups were matched. The donor was a 16-year-old boy who died after traumatic brain injury after a car accident. For organ preservation, University-of-Wisconsin solution (Viaspan, Bristol-Myers Squibb, Munich, Germany) was used. The arterial homograft was cryopreserved using a standardized freezing protocol. Immunosuppression was started 2 weeks after the operation and was maintained using the calcineurin inhibitor FK506 (1 mg/d).After an uncomplicated recovery and discharge from the hospital, the patient rapidly developed multiple false aneurysms during the first 3 postoperative months (Figure 1). The aneurysms were detected during routine follow-up ultrasound. Two large pseudoaneurysms emerged at the level of central anastomosis, and 2 false saccular aneurysms developed on the right leg and 4 on the left leg of the homograft (Figure 2). The distal anastomoses remained intact. Because of imminent prosthetic graft reinfection, an endovascular repair approach was used; a unibody stent graft was implanted in combination with a femorofemoral crossover graft for revascularization of the left limb (Figure 2). The patient again recovered smoothly and both grafts remained patent. The histology resembled the typical pattern of arterial homograft degeneration, showing a prominent neointima formation and degenerated media (Figure 3).1 No signs of rejection were present. Therefore, the pseudoaneurysm development was attributed to fractures of the homograft after cryopreservation and thawing.2Download figureDownload PowerPointFigure 1. Multiple saccular pseudoaneurysms developed at site of central anastomosis and at both legs of the aorto-bifemoral homograft 3 months after implantation (intra-arterial digital subtraction angiography).Download figureDownload PowerPointFigure 2. Magnetic resonance angiographies at discharge (A), at the 3-month follow-up (B), and after endovascular repair in combination with a femorofemoral crossover graft (C).Download figureDownload PowerPointFigure 3. Histology of the homograft femoral artery taken after cryopreservation (A) and at surgery after 3 months (B). The homograft wall showed a degenerated media and a prominent neointima formation. NI indicates neointima; M, media.DisclosuresNone.FootnotesCorrespondence to Michael Heise, MD, Charité, University Medicine, Department of General Surgery, Augustenburger Platz 1, 13353 Berlin, Germany. E-mail [email protected]References1 Vogt PR, Stallmach T, Niederhauser U, Schneider J, Zund G, Lachat M, Kunzli A, Turina MI. Explanted cryopreserved allografts: a morphological and immuno-histochemical comparison between arterial allografts and allograft heart valves from infants and adults. Eur J Cardiothorac Surg. 1999; 15: 639–644.CrossrefMedlineGoogle Scholar2 Pegg DE, Wusteman MC, Boylan S. Fractures in cryopreserved elastic arteries. Cryobiology. 1997; 34: 183–192.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Soquet J, Chambon J, Goffin Y and Jashari R (2014) Acute rejection of a cryopreserved arterial homograft, Cell and Tissue Banking, 10.1007/s10561-014-9489-y, 16:3, (331-333), Online publication date: 1-Sep-2015. Bia D, Zócalo Y, Armentano R, Pérez-Cámpos H, Fernández-Pin J, Panuncio A, Saldías M, Mariño A and Álvarez I (2012) Post-implant evaluation of the anastomotic mechanical and geometrical coupling between human native arteries and arterial cryografts implanted in lower-limb, Cryobiology, 10.1016/j.cryobiol.2011.09.133, 64:1, (50-59), Online publication date: 1-Feb-2012. Utsumi T, Ohtsuka M, Uchida E, Yamaguchi H, Nakajima T, Akazawa H, Takano H, Nakaya H and Komuro I (2008) Abdominal aortic pseudoaneurysm caused by prolonged methicillin-resistant Staphylococcus aureus sepsis, International Journal of Cardiology, 10.1016/j.ijcard.2007.06.043, 128:2, (294-295), Online publication date: 1-Aug-2008. August 1, 2006Vol 114, Issue 5 Advertisement Article InformationMetrics https://doi.org/10.1161/CIRCULATIONAHA.105.605436PMID: 16880334 Originally publishedAugust 1, 2006 PDF download Advertisement SubjectsAngiographyCardiovascular SurgeryComputerized Tomography (CT)