Abstract
1. (1) A spectrophotometric method for the quantitative determination of isonicotinic acid hydrazide (INH) in whole blood is described. 2. (2) The method involves reaction of INH with 2,4,6-trinitrobenzenesulphonic acid and extraction of the coloured product into methyl isobutyl ketone. The absorbance of the extract at 500 nm is proportional to INH concentration up to 30 μg/ml. 3. (3) Streptomycin and known metabolites of INH do not react, but p-amino-salicylic acid should be absent.
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