Abstract
The human leukocyte antigen (HLA) genes help the immune system recognize and respond to foreign substances and pathogens. A version of HLA-B gene designated as HLA-B*5701, has been associated with hypersensitivity to Abacavir, a highly effective drug used to treat HIV infection. A single nucleotide polymorphism in human HCP5 gene known as rs2395029 (G) allele is 99.9% predictive of the presence of HLA-B*5701. Here, we report a tetra-primer amplification refractory mutation system PCR that provides a rapid, reproducible, cost-effective and accurate method to genotype HLA-B*5701 allele.
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