Abstract

Adverse drug reactions have increased dramatically worldwide, often preventing the use of first-line therapies. Not infrequently, many patients presenting with drug hypersensitivity reactions are irreversibly labeled as allergic, fact that prevents them to receive the most appropriate treatment for their illnesses. Rapid drug desensitization has become a cornerstone in the management of immediate drug hypersensitivity reactions. It is the only effective procedure for overcoming hypersensitivity reactions to first-line therapy, thus representing an important advance in patients’ treatment and prognosis. Continued reports on the safety and efficacy of rapid drug desensitization emerging from different institutions are essential to allow the dissemination of desensitization programs.

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