Abstract

The acute administration of ketamine depletes methionine-enkephaline levels in rat striatum, as measured by radioimmunoassay. The maximum decrease of about 25% was observed 30 minutes after 100 mg.kg −1, i.p. injection of the drug, enkephalin levels returning to normal within 90 minutes. Neither higher doses nor a double administration of ketamine produced any further depletion. These results indicate that ketamine interacts with the enkephalinergic system and suggests the presence of a limited and rapidly releasable pool of methionine-enkephaline in the brain.

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