Abstract
Objective: To investigate the effect of metformin on testosterone levels in men with type 2 diabetes mellitus (T2DM). <p>Methods: Seventy men with newly diagnosed drug naïve T2DM, HbA<sub>1c</sub> >9.0% (75mmol/mol) were treated with intensive insulin pump therapy for 5 days to achieve glucose normalization. They were randomized to control (continued on intensive insulin only) and metformin (plus metformin) groups (1:1) for one month. Testosterone was measured at baseline, randomization, and after one-month treatment. </p> <p>Results: Total, free and bioavailable testosterone increased significantly within 5 days (all <i>p</i><0.001). After one month, compared to controls, the metformin group had lower total (12.7 vs 15.3 nmol/L), free (0.20 vs 0.24 nmol/L), and bioavailable (4.56 vs 5.31 nmol/L) testosterone (<i>p</i> all <0.05).</p> <p>Conclusions: In men with T2DM, one-month oral metformin may decrease serum testosterone levels independent of blood glucose control. The effects of long-term metformin on testosterone in men need further study.</p>
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