Abstract
Goal. We assessed the effectiveness of bioactive polyphenols contained in solution (LX) to restore normal bowel function in pediatric patients with acute diarrhea.Background. While providing oral rehydration solution (ORS) is standard treatment for diarrhea in developing countries, plant-derived products have been shown to positively affect intestinal function. If a supplement to ORS resolves diarrhea more rapidly than ORS alone, it is an improvement to current care.Study. In a randomized, double-blind, placebo-controlled cross-over study, 61 pediatric patients with uncontrolled diarrhea were randomized to receive either ORS + LX on day 1 and then ORS + water on day 2 (study arm) or ORS + water on day 1 and then ORS + LX on day 2 (control arm). Time to resolution and number of bowel movements were recorded.Results. On day 1, the mean time to diarrhea resolution was 3.1 h (study arm) versus 9.2 h (control arm) (p = 0.002). In the study arm, 60% of patients had normal stool at their first bowel movement after consumption of the phenolic redoxigen solution (LX). On day 2, patients in the study arm continued to have normal stool while patients in the control arm achieved normal stool within 24 h after consuming the test solution. Patients in the control arm experienced a reduction in the mean number of bowel movements from day 1 to day 2 after consuming the test solution (p = 0.0001). No adverse events were observed.Conclusions. Significant decreases in bowel movement frequency and rapid normalization of stool consistency were observed with consumption of this novel solution.
Highlights
Diarrhea is the second leading cause of death in children under the ages of 5 years in developing countries (Johansson, Wardlaw & Binkin, 2009), a most concerning statistic as diarrhea may be prevented and treated
With approval of the institutional review board of the Universidad Centroamericana de Ciencias Empresariales (IRB 2010013, registered ISRCTN57765025)), treatment-naıve, previously healthy pediatric patients between 2 and 17 years of age who arrived at the clinic with uncontrolled acute diarrhea within 48 h prior to presentation were enrolled in the study
Patient demographics A total of 61 patients were enrolled in this study with patients randomized to the study arm (ORS + LiveXtract solution (LX)) and patients to the control arm (ORS + water) on day 1
Summary
Diarrhea is the second leading cause of death in children under the ages of 5 years in developing countries (Johansson, Wardlaw & Binkin, 2009), a most concerning statistic as diarrhea may be prevented and treated. Acute diarrhea can lead to severe dehydration and electrolyte imbalance by loss of fluids, electrolytes, and nutrients (Munos, Fischer Walker & Black, 2010). Oral rehydration therapy was initially developed to replace cholera-induced fluid loss (Pierce et al, 1969; Sentongo, 2004), but has expanded to include diarrhea incited. How to cite this article Dover et al (2015), Rapid cessation of acute diarrhea using a novel solution of bioactive polyphenols: a randomized trial in Nicaraguan children. ORS assists in diarrheal management, it does not reduce the duration of diarrhea or fecal volume (Canai et al, 2007). Instead, implementing ORS can increase stool volume in children during acute episodes (Sarker et al, 2001; El-Mougi et al, 1994). In order to optimize efficacy, the WHO recommended a modified ORS with reduced osmolarity, administration of zinc gluconate, non-digestible carbohydrates, rice powder, and probiotic bacteria—all with mixed results (Gregorio et al, 2007; Basu et al, 2007; Narayaappa, 2008; Hoekstra et al, 2004; Passariello et al, 2011)
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