Abstract

The axonal transport [ 3H]leucine-labeled proteins in sensory fibers of rabbit vagus nerve was studied at various times after the nerves had been crushed in vivo. Up to 8 weeks after the crush, proteins transported from the nodose ganglion accumulated at the site of the crush under in vitro incubation conditions. This was in contrast to transport in sensory vagal fibers in vivo, which continued distal to the crush zone into the newly-regenerated fibers. Motor fibers in the vagus nerve behaved similarly; in vitro incubation conditions which support transport in mature nerves were unable to support it in newly-grown fibers. Four or five months after the crush some transport occurred in the regenerated axons in vitro, but accumulation still occurred at the crush zone.

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