Abstract
A convergent and efficient strategy for the synthesis of high-mannose oligosaccharides is described wherein regioselective glycosylations between trichloroacetimidate donors and partially protected acceptors are employed to reduce the number of protection–deprotection steps. Two representative branched mannose oligosaccharides, a mannose heptasaccharide (Man7) and a mannose nonasaccharide (Man9) were constructed via (4 + 3) and (5 + 4) glycosylations, respectively. These mannose-containing oligosaccharides were obtained in nine steps in ∼25% overall yield and >98% purity on 60–70 mg scales to demonstrate the effectiveness of the strategy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have