Abstract
We present a new approach for the screening method of Lysergic Acid Diethylamide (LSD) in blotter papers using square wave voltammetry with a Boron-Doped Diamond Electrode (BDDE). The LSD electrochemical detection is based on an oxidation process at the BDDE in 0.1 mol L−1 acetate buffer pH 4.0. The BDDE exhibited a highly stable response for LSD oxidation (peak current and peak potential) with a relative standard deviation lower than 1.6 % (N = 10). The linear range for LSD determination spans over two orders of magnitude (5.0–100 μmol L−1) with an excellent linear regression coefficient (r2 > 0.999) and a LOD of 0.5 μmol L−1, which is sufficiently low to detect this drug in seized samples. An interference study for LSD detection in seized blotter papers was performed for twenty (20) synthetic drugs belonging to the phenethylamines derivative groups. The analytical performance of the proposed approach revealed itself as an easy, rapid, and selective screening method for the detection of LSD in blotter papers and other presentation formats.
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