Abstract
ABSTRACTNowadays, the abuse of illegal drugs has been an increasingly grim problem in the world. Excitation–emission matrix fluorescence combined with parallel factor analysis was used to make a quantitative analysis of the simulated amphetamine-type illegal drugs. Satisfactory results were achieved for simultaneous determination of methamphetamine (MAM) and 3, 4-methylenedioxymethamphetamine (MDMA) in the presence of adulterants. The average recoveries were (99.8 ± 0.6)% and (101.6 ± 5.7)% for MAM and MDMA, respectively. Figures of merit including root-mean-square error of calibration and prediction, sensitivity and selectivity were investigated to evaluate the performance of the proposed method. The limits of detection were 0.054 and 0.002 1 μg/mL for MAM and MDMA, respectively.
Highlights
According to the recently available World Drug Report 2016, the number of illegal drug users has risen rapidly over the last five years
MAM exhibited a strong peak around λex/λem = 256/288 nm; MDMA was characterized by the presence of two peaks around λex/λem = 282/322 and 234/322 nm
Similar spectra were found among MAM, AM and PSE due to the minor structural differences of the three substances; one strong peak appeared at 256/288 nm for both AM and PSE
Summary
According to the recently available World Drug Report 2016, the number of illegal drug users has risen rapidly over the last five years. Amphetamine-type stimulants (ATS) such as methamphetamine (MAM) and 3, 4-methylenedioxymethamphetamine (MDMA), two of the most common ATS known as “ice” and “ecstasy”, are widely abused among young people. These illegal drugs are potent in stimulating the central nervous system, reducing fatigue and inducing euphoria. Continuous use of those illegal drugs will make a person produce psychological dependence. The adulterants in the tablets may enhance the stimulant effects of drug mixture, disguise the existence of illicit drugs or use for secret substitution of a more expensive illicit drug with a cheaper substance. A more rapid method for simultaneous determination of ATS in a mixture with adulterants would be highly desirable for efficient battle against illegal drug trafficking
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