Abstract
Urine Luck, the main component of which is pyridinium chlorochromate (PCC), is a popular adulterant used to conceal drugs present in urine samples. Electrospray ionization mass spectrometry with direct flow injection was employed to identify and quantitate PCC after complex formation of chromium (Cr6+) in PCC with diethyldithiocarbamate and its extraction with isoamyl alcohol. The quantitation was performed by selected ion monitoring at m/z 513, and the detection limit was 20 pg PCC (equivalent to 5pg Cr6+) in 1 µl of an injected volume. The integrated area of the mass chromatogram was proportional to the amount up to 2000 pg PCC with the limit of quantitation of 60 pg PCC in an injected volume. The recoveries of PCC from 50µl of urine spiked at 10−7 and 10−6M were 93% and 95%, respectively. The present method for analysis of Urine Luck is recommended for use in forensic analysis because of its speed, high sensitivity, and high specificity.
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