Rapid and sensitive analytical strategy for multi-class antibiotic residues analysis in aquatic products with amphiphilic magnetic polymer particles as an effective cleanup adsorbent

Abstract

Multi-class antibiotic analysis in aquatic products is still challenging owing to the complex matrix and low co-extraction efficiency of various antibiotics. A facile and sensitive sample pretreatment method based on magnetic dispersive solid-phase extraction was thus developed via systematic optimization of extraction and purification procedure. The multi-class antibiotics can simultaneously be extracted by acetonitrile-2 % acetic acid. Amphiphilic magnetic particles and C18 were used as adsorbents to remove matrix interferences, affording significantly reduced matrix effects of analytes. Under the optimum conditions, satisfactory linearity, recovery, precision, and sensitivity were achieved. The method limits of quantification were 0.25–0.5 μg kg−1. Besides, it displayed obvious advantages in operation convenience and efficiency due to the usage of magnetic particles. The developed method was successfully used to analyze antibiotic residues in both freshwater and seafood products, manifesting its suitability for antibiotic residues analysis in aquatic products.