Abstract
In order to prepare new anti-retroviral nucleoside analogues, the effect of the group at C-5′ on the addition of lithium and cerium trimethylsilylacetylide on 3′-ketonucleosides (R 1 = H, R 1 = TBDMS) derived from adenosine and uridine was studied. The best results in respect of yield (56 to 81%) and diastereoselectivity (95:5 to >98:2) were obtained with a cerium reagent (RCeCl 2).
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