Abstract
Ionic liquids (ILs) have gained much attention as alternative solvents to volatile organic solvents due to their attractive properties. This study aimed to develop an efficient method for the selective separation of decursin (D) and decursinol angelate (DA) from Angelica gigas Nakai (A. gigas) using ILs and crystallization. The IL 1-butyl-3-methylimidazolium tetrafluoroborate ((BMIm)BF4) was the most efficient at extracting D and DA. Parameters including solid-to-liquid ratio, time, and temperature were optimized by response surface methodology (RSM). Under optimal extraction conditions (1 g/6.5 mL solid-to-liquid ratio, 60 °C temperature, and 120 min time), the extraction yields of D and DA were 43.32 mg/g (97.06%) and 17.87 mg/g (97.12%), respectively. Moreover, drowning out crystallization using deionized water (DW) as an anti-solvent offered an excellent ability to recover D and DA from the A. gigas–(BMIm)BF4 extraction solution. The rates of recovery and the total purity of D and DA were found to be greater than 97%. Therefore, a rapid and efficient method of combining ILs with crystallization was effectively achieved for the selective separation of D and DA. This approach is assumed to be beneficial in the pharmaceutical industry for the effective obtention of D- and DA-enriched products.
Highlights
Angelica gigas Nakai (A. gigas) is a Korean medicinal herb for which the dried roots have been extensively used in the Korean pharmacopoeia for the treatment of several diseases such as neuralgia, headache, cold, arthralgia, gynecological disorders, etc
The extraction conditions were optimized by Response Surface Method (RSM)
Gigas–(BMIm)BF4 extraction solution when deionized water (DW) was used as an anti-solvent
Summary
Angelica gigas Nakai (A. gigas) is a Korean medicinal herb for which the dried roots have been extensively used in the Korean pharmacopoeia for the treatment of several diseases such as neuralgia, headache, cold, arthralgia, gynecological disorders, etc. The pyranocumarins, decursin (D) (Figure 1a) and decursinol angelate (DA) (Figure 1b) are reported as the principal bioactive compounds of this plant [1,2,3]. The extensively used indevelopment the Korean pharmacopoeia for theable treatment of several diseases such neuralgia, of a novel approach to improve the extraction yield,asrecovery, as well as the purity headache, cold, arthralgia, gynecological disorders, etc. 1a) and decursinol angelate (DA) (Figure 1b) are reported as the principal bioactive compounds of his plant [1,2,3].
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