Rapid Analysis of some Endocrine Disruptor Chemicals Leaching from Baby Milk Feeding Bottles Using SPME and SDME Techniques

Abstract

The sample preparation methods such as the solid-phase microextraction (SPME) and the single-drop microextraction (SDME) for preconcentration of some endocrine disruptor chemicals (EDCs) leaching from baby milk feeding bottles were developed. Afterwards, all analytes were determined by using the GC-MS technique. The parameters affecting extraction efficiency of both methods including fiber coating, extraction time, extraction temperature, salting-out effect, desorption time, organic solvent, drop volume, pH of the solution, and stirring rate were also investigated. Under the optimum extraction conditions, the results from the developed methods revealed that the analysis time used was somewhat short (<8 min). The detection limits was low (LOD, 0.02–0.12 μg/mL for direct-SPME and 0.07–0.17 μg/mL for direct-SDME). The precision was slightly satisfactory (RSD, <5.9% of intra-day, <7.9% of inter-day for direct-SPME and <4.3% of intra-day, <4.7% of inter-day for direct-SDME). Moreover, the recoveries in both techniques were slightly high (85–102% for direct-SPME and 84–103% for direct-SDME). In this regard, both direct-SPME and direct-SDME methods could be used as alternative ways for the sensitive determination of some EDCs. Besides, the simple, rapid, and efficient features of the proposed method were demonstrated by the analysis of these compounds in aqueous solution.