Abstract
Two organic molecular crystalline species, ibuprophen (IB) and indomethacine (IM) were subjected to methanol absorption in the presence of hydrophilic organic matrix, hydroxypropyl methylcellulose (HPMC). While spraying of 8–10% methanol or water on the drug–matrix mixture decreased the subsequent milling time for amorphization, absorption of methanol in a closed container caused spontaneous amorphization of IB was observed to give a nanocomposites with macroscopic agglomerates up to 250 μm after methanol absorption for overnight. Gentle mechanical homogenization under saturated methanol vapor with a newly developed apparatus, a tandem rotation mill (TRM), brought about homogeneous grains of IB-HPMC nanocomposites with the average particle size, 30 μm. We observed amorphous particles of IB in 60 nm regime dispersed in HPMC matrix under a transmission electron microscope (TEM). In the case of IM, mechanical homogenization with TRM was indispensable to obtain similar nanocomposites with HPMC.
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