Abstract
Microwave heating of triethylsilyl (TES)‐ and tert‐butyldimethylsilyl (TBS)‐protected 1° and 2° alcohols in a mixture of equal parts acetic acid, tetrahydrofuran (THF), and water allows deprotection in as little as 5 min. tert‐butyldiphenylsilyl (TBDPS)‐ and triisopropylsilyl (TIPS)‐protected alcohols and silyl‐protected phenols are stable in these conditions. Thus, selective deprotection of TES‐ and TBS‐protected alcohols in the presence of TIPS or TBDPS ethers is possible. Similarly, alkyl silyl ethers can be deprotected in the presence of aryl silyl ethers.
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