Abstract
The specific activities of brain and plasma H3-tryptophan and brain H3-serotonin increased approximately linearly for only 6 min after animals received intraperitoneal tracer doses of H3-tryptophan. The maximum rate of brain serotonin synthesis could thus be estimated from data collected during this interval, but not thereafter. Pretreatment of rats with intraventricular 5, 6-dihydroxytryptamine, a compound that damages serotoninergic neurons, decreases brain tryptophan and serotonin concentrations, accelerates the labelling of brain tryptophan by injected H3-tryptophan, and markedly decreases the rate at which H3-tryptophan accumulates as brain H3-serotonin. The treatment of oophorectomized rats with estradiol and progesterone does not appear to modify brain serotonin synthesis.
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