Abstract
Abstract Food-derived bioactive peptides have received considerable attention as low toxicity nutrient supplements with multiple physiological activities, such as antioxidant, antihypertensive and anti-inflammatory properties. In this study, a RAW 264.7 cell model and spontaneously hypertensive rats model were employed to investigate the antioxidant and anti-inflammatory activities of the angiotensin I-converting enzyme inhibitory peptides Leu-Tyr (LY), Arg-Ala-Leu-Pro (RALP) and Gly-His-Ser (GHS). The results showed that in vitro, LY, RALP and GHS significantly inhibited the secretion of nitric oxide, interleukin-6 and tumor necrosis factor-α in lipopolysaccharide-stimulated RAW 264.7 macrophages. In vivo, LY, RALP and GHS inhibited the release of nitric oxide and the production of lipid peroxides and reactive oxygen species, and improved cell damage caused by oxidative stress in spontaneously hypertensive rats. Furthermore, LY, RALP, and GHS inhibited proinflammatory cytokines including interleukin-6 and tumor necrosis factor-α in plasma. Thus, LY, RALP and GHS can protect the body from oxidative and inflammatory damage.
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