Rapamycin treatment exacerbates age-related oa severity in the Dunkin-Hartley guinea pig

Abstract

Purpose: Osteoarthritis (OA) is generally categorized into two types. Post-traumatic (secondary) OA develops following acute joint trauma, and age-related (primary) OA develops slowly over the course of decades. There is mounting evidence for genes and signaling pathways playing inconsistent or opposing roles in the progression of primary and secondary OA. This suggests that, while primary and secondary OA may present with similar end-stage pathology, the mechanisms driving these two OA subtypes are likely unique and warrants testing of therapeutic targets in both forms.