Abstract
ObjectiveThe G-403A polymorphism in RANTES gene may be involved in the development of coronary artery disease (CAD) through increasing RANTES-mediated leukocyte trafficking and activation. However, studies investigating the relationship between G-403A polymorphism and CAD yielded contradictory and inconclusive results. In order to shed some light on these inconsistent findings, a meta analysis was performed to clarify the role of G-403A polymorphism of RANTES gene in the susceptibility of CAD.MethodsA systemic literature search of PubMed and EMBASE was conducted from their inception to March 23, 2012, to retrieve related studies. In addition, Conference Proceedings Citation Index-Science was searched, authors of relevant studies were contacted, and reference lists of the included studies and their related citations in PubMed were reviewed for additional pertinent studies.ResultsA total of 8 eligible studies were identified, with a total of 4252 CAD cases and 2150 controls. There was no evidence of significant association between G-403A polymorphism and CAD risk in any genetic model or pairwise comparisons (additive model: OR = 1.046, 95% CI = 0.883–1.239, I2 = 65.9%; recessive model: OR = 1.140, 95% CI = 0.774–1.678, I2 = 53.1%; dominant model: OR = 1.000, 95% CI = 0.820–1.21), I2 = 62.6%; AA vs GG: OR = 1.141, 95% CI = 0.734–1.773, I2 = 61.2%; GA vs GG: OR = 0.993, 95% CI = 0.800–1.232, I2 = 64.6%). Subgroup analysis and meta regression indicated that ethnicity and genotyping method accounted for the significant heterogeneity among studies. In the stratified analysis by ethnic group, G-403A polymorphism was found to be associated with increased CAD risk in Caucasian population whereas its protective role was observed in Asian population in some but not all comparisons.ConclusionData from the current meta-analysis do not support the existence of a relationship between G-403A polymorphism and the development of CAD, and large sample size study employing unified genotyping method is needed to further evaluate the influence of G-403A polymorphism on susceptibility of CAD.
Highlights
It has been widely accepted that atherosclerosis is an inflammatory disease mediated by intense immunological activity, a process characterized with the accumulation and activation of the inflammatory and immune cells within the vessel wall [1]
Some clinic-based observational studies have reported that G403A polymorphism was associated with the susceptibility of coronary artery disease (CAD) [9,10]
Conference proceedings were searched in Conference Proceedings Citation Index-Science (CPCI-S) and authors of relevant studies were contacted via email and asked for any other published or unpublished studies that might contribute to the meta-analysis
Summary
It has been widely accepted that atherosclerosis is an inflammatory disease mediated by intense immunological activity, a process characterized with the accumulation and activation of the inflammatory and immune cells within the vessel wall [1]. The extravasation of the circulating monocyte and lymphocyte from the peripheral blood to the intima is the most pronounced event in the early stages of atherogenesis [2] The recruitment of these cells to vascular wall is mainly guided by endothelial leukocyte adhesion molecules and chemoattractants [3]. Given their fundamental role in the inception of atherosclerosis, chemokines and their receptors have been the focus of intensive researching during the past decades. Some clinic-based observational studies have reported that G403A polymorphism was associated with the susceptibility of coronary artery disease (CAD) [9,10]. We performed a meta analysis of available studies with a case-control or cohort
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