Abstract
Objective. To investigate the efficacy of application of autologous mesenchymal stem cells (AMSC) in treatment of patients, suffering critical ischemia of the lower extremities (CILE). Маterials and methods. In 2012 - 2015 yrs there was conducted the treatment of 41 patients, suffering CILE: 22 (53.7%) - men, and 19 (46.3%) - women. In the Group I (the main) 21 (51.2%) patients have had obtained a standard course of treatment, using AMSC. In the Group II (the control one) 20 (49.8%) patients have obtained a standard course of conservative treatment, using prostaglandins of group Е1 (PGЕ1). The results were investigated, measuring ankle-brachial pressure index, and the indices of a laser duplex flowmetry and a walking distance.
 Results. During a one-year follow-up a trustworthy enhancement of microcirculation index was registered in the patients, who were treated, using AMSC, comparing with the patients, who obtained a course of therapy of PGЕ1 (р=0.037). Positive dynamics of the microcirculation index while a PGЕ1application was observed during (1.8 ± 0.3) mo, аnd while application of AMSC the microcirculation index have been enhanced trustworthily in (2.7 ± 0.4) mo and persisted during one-year of follow-up.
 Conclusion. Development of therapeutic effect in groups of patients, who were treated with AMSC and PGЕ1, did not occur simultaneously, thus , a complex treatment with simultaneous application of both methods and conduction of a dosed physical training may be considered a rational option.
Highlights
Peripheral artery disease (PAD) is a significant medical and social challenge for both patients from low–income and developed countries
The results demonstrate an improvement in Laser doppler flowmetry (LDF) results among the control group patients that evidences the early therapeutic effect of prostaglandin E1 (PgE1)
A positive dynamic change of the microcirculation rate in case of PgE1 treatment is shown for 1.8 ± 0.3 months, whereas autologous mesenchymal stem cells (AMSC) treatment demonstrates a significant increase in the microcirculation rate for 2.7 ± 0.4 months that was observed during the one–year period
Summary
Peripheral artery disease (PAD) is a significant medical and social challenge for both patients from low–income and developed countries. According to recent statistical reports, more than 250 million people all over the world are suffering from PAD, the majority of whom represent the developing countries. Http: //hirurgiya.com.ua mately 70% of all patients, namely 140.8 million people, live in regions with low or middle income per capita, with PAD incidence increased among them by 29% over the past decade. The high prevalence of the disease and ineffective treatments (surgical interventions aimed to restore the patency of arterial vessels and make bypass shunts) cause the need for further research and development of fundamentally new approaches to PAD therapy [3]
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