Rank tests for patterned alternatives in two-way non-parametric analysis of variance

Abstract

We consider the problem of testing against trend and umbrella alternatives, with known and unknown peak, in two-way layouts with fixed effects. We consider the non-parametric two-way layout ANOVA model of Akritas and Arnold (J. Amer. Statist. Assoc. 89 (1994) 336), and use the non-parametric formulation of patterned alternatives introduced by Akritas and Brunner (Research Developments in Probability and Statistics: Festschrift in honor of Madan L. Puri, VSP, Zeist, The Netherlands, 1996, pp. 277–288). The hypotheses of no main effects and of no simple effects are both considered. New rank test statistics are developed to specifically detect these types of alternatives. For main effects, we consider two types of statistics, one using weights similar to Hettmansperger and Norton (J. Amer. Statist. Assoc. 82 (1987) 292) and one with weights which maximize the asymptotic efficacy. For simple effects, we consider in detail only statistics to detect trend or umbrella patterns with known peaks, and refer to Callegari (Ph.D. Thesis, University of Padova, Italy) for a discussion about possible statistics for umbrella alternatives with unknown peaks. The null asymptotic distributions of the new statistics are derived. A number of simulation studies investigate their finite sample behaviors and compare the achieved alpha levels and power with some alternative procedures. An application to data used in a clinical study is presented to illustrate how to utilize some of the proposed tests for main effects.