Abstract
Letters and Corrections1 January 1990Ranitidine-Warfarin InteractionAnne M. Baciewicz, PharmD, Peter J. Morgan, MDAnne M. Baciewicz, PharmDSearch for more papers by this author, Peter J. Morgan, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-1-76_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We report a possible prolongation of prothrombin time (PT) of warfarin by ranitidine. A 65-year-old woman with a past medical history of a cerebral vascular accident and an aortic valve replacement was discharged from the hospital with a diagnosis of recurrent deep-vein thrombosis, recurrent gastrointestinal bleeding, and iron-deficiency anemia. Four days before discharge, the ranitidine dose was increased to 600 mg daily because on the recommended 300-mg daily maintenance dose for several months the patient developed recurrent gastrointestinal bleeding. At discharge, her medications (all taken orally) included warfarin, 5 mg once daily; ranitidine, 300 mg twice daily;...
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