Abstract
A new and efficient method of synthesizing primary amines from their corresponding nitriles with KBH4 in dry ethanol catalyzed by Raney Ni has been discovered. It is proved that this route is so far the most facile, efficient and easy-to-handle method of reducing aliphatic and aromatic nitriles directly to primary amines. Under mild conditions, up to 93% isolated yields were achieved for aromatic or aliphatic nitriles. This approach opens up a new way for the utilization of potassium borohydride and the classical catalyst Raney Ni.
Highlights
Nitrile hydrogenation is an important method to obtain amines
The difficulty arises because the imine, as an intermediate produced by the reduction of cyano group, could couple with an already formed primary amine, which leads to secondary amine
Khurana et al 7 reported that aromatic nitriles could be reduced to primary amines with NaBH4 using NiCl2 as additive
Summary
Nitrile hydrogenation is an important method to obtain amines. Khurana et al 7 reported that aromatic nitriles could be reduced to primary amines with NaBH4 using NiCl2 as additive. Longer synthesis routes were needed and the yields of primary amines are not high enough.
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