Abstract
This double-blinded and split-mouth design, randomized feasibility study aimed to assess the efficacy of prophylactic and therapeutic use of a new age NitrAdineTM-based brushing solution (PerioTabs®) on the clinical parameters before and after periodontal therapy. Four subjects were randomly assigned to two treatment groups according to periodontal infection: PerioTabs® and placebo. At the first appointment, a split-mouth scaling was performed in all participants. All oral care instructions concerning the use of effervescent tablets were explained to the participants in detail. The morning after the tablets were finished, a full-mouth scaling was completed in all participants. All parameters were recorded at 0, 11, and 40 days. According to the results, both the therapeutic and prophylactic interventions showed similar impacts on the gingival index and probing depth compared to the placebo in all patients. The bleeding on probing was further reduced at the PerioTabs® group at baseline until day 40 compared to the placebo in the gingivitis patients with both interventions; at both 11 and 40 days in the periodontitis patients receiving the therapeutic intervention; and at baseline to day 40 in the periodontitis group receiving the prophylactic intervention. While the preliminary results of this new-age brushing solution appear to be a promising approach for a future therapy of periodontal diseases, further research on a larger sample size is needed to draw firm conclusions.
Highlights
Received: 29 November 2021Periodontal inflammation is a significant health problem due to its high prevalence worldwide [1]
Dental plaque-induced gingivitis caused by inadequate oral hygiene is a reversible inflammatory reaction, and the primary clinical parameter of gingivitis is excepted bleeding upon gentle probing in the last classification of periodontal conditions [2]
We describe the use of a new gum brushing solution that is based on the antimicrobial NitrAdineTM formula, called “PerioTabs® ”
Summary
Received: 29 November 2021Periodontal inflammation is a significant health problem due to its high prevalence worldwide [1]. Periodontal health means more than the quality oral health; it is an integral part of general health. Dental plaque-induced gingivitis caused by inadequate oral hygiene is a reversible inflammatory reaction, and the primary clinical parameter of gingivitis is excepted bleeding upon gentle probing in the last classification of periodontal conditions [2]. The prevention of periodontitis involves both the treatment of existing gingivitis and the prevention of future occurrences. Initial periodontal therapy consists of non-surgical periodontal therapy, including supragingival calculus removal, tooth surface polishing, scaling and root planing (SRP), the elimination of plaque retentive factors, and oral hygiene advice to facilitate the long-term maintenance of healthy periodontal tissue. SRP is the most commonly used treatment approach in initial periodontal therapy, but clinical treatment alone is futile if the patient is unable to implement adequate oral hygiene. The oral cavity is the beginning of the gastrointestinal tract and is continuously subjected to internal and external influences, Accepted: 28 January 2022
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