Abstract
Objective: Despite advances, overall prognosis for advanced epithelial ovarian cancer (EOC) remains poor. Considering elevated TGFβ expression correlates with poor prognosis in ovarian cancer, this study aims to determine whether a maintenance vigil could provide improvement in relapse-free survival. Vigil is an autologous tumor cell vaccine constructed from autologous harvested tumor tissue transfected with a DNA plasmid encoding GMCSF and bi-shRNA-furin, thereby creating TGFβ expression control.
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