Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee- Letter to the Editor &amp; Author Response

Sandeep Patel,Mandeep Singh Dhillon ,Tungish Bansal

doi:10.46582/jsrm.1302012

Abstract

Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee- Letter to the Editor & Author Response

Highlights

1) The authors have used high molecular weight hyaluronic acid (2.4-3.6 MDa) in concentration of 10mg/ml, ie 1% w/v (Eufflexa-Ferring 10mg/ml HA) and HA has been used with PRP in the ratio of 1:2.5
The sample size of the study seems inadequate for it to be labelled as an RCT as per CONSORT guidelines
Considering the absence of a true control group (Saline Placebo), and as both HA and PRP are established as treatment modalities in relieving pain in Knee OA, the sample size should have been larger to demonstrate a significant difference between the treatment groups

Summary

Introduction

1) The authors have used high molecular weight hyaluronic acid (2.4-3.6 MDa) in concentration of 10mg/ml, ie 1% w/v (Eufflexa-Ferring 10mg/ml HA) and HA has been used with PRP in the ratio of 1:2.5. Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee.

Results

Conclusion