Abstract
SummaryFifty-six patients with severe intra-abdominal infection have been included in a controlled randomized open study. Imipenem/cilastatin was administered to 28 patients. The remaining 28 patients received ceftazidime, including 7 patients who received a combination of ceftazidime with metronidazole. The difference in cure rates did not reach statistical difference, although 3 failures were reported in the ceftazidime group and none in the imipenem/cilastatin group.Based on 100 pretreatment antibiograms, far more organisms were susceptible to imipencm (99) than to ceftazidime (80) (p < 0.001). The Presence of a pathogen resistant to therapy in the follow-up culture was observed more frequently in the ceftazidime group (p < 0.05).Tolerance and safety profile were good in both groups.It is concluded that imipenem/cilastatin is an efficient empiric monotherapy in severe intra-abdominal infections.
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