Abstract
BackgroundBibersteinia trehalosi causes respiratory disease in ruminants particularly in wild and domestic sheep. Recently, there has been an increased number of B. trehalosi isolates obtained from diagnostic samples from bovine respiratory disease cases. This study evaluated the role of B. trehalosi in bovine respiratory disease using an intra-tracheal inoculation model in calves. Thirty six cross bred 2–3 month old dairy calves were inoculated intra-tracheally with either leukotoxin negative B. trehalosi, leukotoxin positive B. trehalosi isolate, Mannheimia haemolytica, a combination of leukotoxin negative B. trehalosi and M. haemolytica or negative control. Calves were euthanized and necropsy performed on day 10 of study.ResultsB. trehalosi inoculated calves did not have increased lung involvement compared to control calves. Additionally, B. trehalosi was only cultured once from the lungs of inoculated calves at necropsy.ConclusionsBased on these findings B. trehalosi may not be a primary pathogen of respiratory disease in cattle. Culture of B. trehalosi from diagnostic submissions should not be immediately identified as a primary cause of respiratory disease.
Highlights
Bibersteinia trehalosi causes respiratory disease in ruminants in wild and domestic sheep
Culture of B. trehalosi from diagnostic submissions should not be immediately identified as a primary cause of respiratory disease
The leukotoxin-PCR-positive B. trehalosi isolate was cultured from the lungs, along with a Pasteurella multocida, from a feedlot calf that had been treated with antibiotics multiple times for Bovine Respiratory Disease that had fibrinosuppurative bronchopneumonia from a group of 273 kg Southeastern feedlot calves with 16% respiratory morbidity and 10% mortality
Summary
Bibersteinia trehalosi causes respiratory disease in ruminants in wild and domestic sheep. This study evaluated the role of B. trehalosi in bovine respiratory disease using an intra-tracheal inoculation model in calves. B. trehalosi was formerly included in a single species of Pasteurella haemolytica as biotype T [2]. This pathogen was recently reclassified as B. trehalosi on the basis of phylogenetic studies [3]. Diagnostic reports of severe non-responsive Bovine Respiratory Disease (BRD) outbreaks associated with multidrug resistant B. trehalosi have been documented [7]. Clinical manifestations of these strains are often associated
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