Randomized Clinical Trial Comparing Cyanoacrylate Glue Versus Suture Fixation in Lichtenstein Hernia Repair: 7-Year Outcome Analysis.

Abstract

Lichtenstein hernioplasty has relatively low recurrence rate, but chronic inguinal pain may cause harm to the patient. The aim of our study was to compare long-term results of cyanoacrylate glue versus absorbable sutures for mesh fixation in Lichtenstein hernioplasty. Lichtenstein hernioplasty (n=302) was performed under local anesthesia in three hospitals. The patients were randomized to receive either 1ml of butyl-2-cyanoacrylate tissue glue (Glubran®; 151 hernias) or absorbable polyglycolic acid sutures (Dexon®; 151 hernias) for mesh fixation (Optilene® mesh). Short-term results were published previously. Chronic groin pain, foreign body sensation, use of analgesics, recurrence and re-operations were analyzed 7years after surgery. We reached 236 patients (78%) to present study. In the glue group (n=115), there were five (4.3%) and in the suture group (n=121) three (2.5%) recurrent hernias (p=0.491). The prevalence of chronic pain (NRS≥3) in the patients without re-operations was similar in two groups: 15/118 (13%) and 13/111 (12%), respectively (p=0.843). There were no significant differences in the foreign body sensation (8/14, p=0.267) or in the need of analgesics (2/2, p=1.00) between the two study groups. Both cyanoacrylate glue and mesh fixation with absorbable sutures were equal in terms of chronic pain and rate of recurrences in Lichtenstein hernioplasty after 7-year follow-up. NCT00659542.