Randomised controlled trial of high versus ad libitum water intake in patients with autosomal dominant polycystic kidney disease: rationale and design of the DRINK feasibility trial

Ragada El‐Damanawi ,Michael C Lee ,Holly Pavey,Simon Bond,Tess Harris,Laura B Mader ,Yoav Ben-Shlomo,Fiona E Karet ,Ian B Wilkinson ,Przemyslaw Woznowski,Alison Burrows,Richard Sandford ,Thomas F Hiemstra

doi:10.1136/bmjopen-2018-022859

Randomised controlled trial of high versus ad libitum water intake in patients with autosomal dominant polycystic kidney disease: rationale and design of the DRINK feasibility trial

Ragada El‐Damanawi , Michael C Lee + Show 11 more

https://doi.org/10.1136/bmjopen-2018-022859

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Journal: BMJ Open	Publication Date: May 1, 2018
Citations: 16	License type: open-access

Affiliation: University of Cambridge, MRC Clinical Trials Unit, Sciences, Philosophie, Histoire

#Autosomal Dominant Polycystic Kidney Disease #High Water Intake + Show 8 more

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Abstract

IntroductionVasopressin stimulates cyst growth in autosomal dominant polycystic kidney disease (ADPKD) leading to enlarged kidneys, hypertension and renal failure. Vasopressin receptor blockade slows disease progression. Physiological suppression of vasopressin secretion...

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