Abstract
In this work we approach the relationship between redox state and iron overload by noninvasive instrumental techniques. Intracardiac, liver iron and liver fibrosis have been monitored in transfusion-dependent thalassemia patients by magnetic resonance imaging and hepatic transient elastography examinations. These measurements have been matched with a non-invasive, and yet unexplored in clinical practice, evaluation of body’s oxidative stress through measurement of antioxidant carotenoids in skin, by a spectroscopic method based on Raman technology (RRS). The global body’s antioxidant status results from a balance between the level of antioxidants in cells and body fluids, including blood, and pro-oxidant species endogenously produced or coming from external sources. On this basis, the level of skin carotenoids can be considered a biomarker of the entire antioxidant status. In our work the use of RRS method provided information on the redox state of thalassemia patients, which was correlated with the iron status of the patients. Due to the highly adverse effects of accumulated iron, the novel, simple, non-invasive RRS to monitor dermal carotenoids with high compliance of the patients may be a useful tool for the management of thalassemia patients.
Highlights
Raman spectroscopy technology to monitor the carotenoids in skin of thalassemia patients: ered the main reason of the redox imbalance
Palermo, Italy nly Abstract e o In this work we approach the relationship between redox state and iron overload by nons invasive instrumental techniques. u Intracardiac, liver iron and liver fibrosis have l been monitored in transfusion-dependent thaia lassemia patients by magnetic resonance imaging and hepatic transient elastography c examinations
Our group first showed that the plasma levels of main antioxidant vitamins were decreased in thalassemia patients and inversely correlated with both ferritin and indices of liver damage, whereas a remarkably increased level of end-products from peroxidation of lipids and proteins showed a positive correlation with these parameters.[1]
Summary
Raman spectroscopy technology to monitor the carotenoids in skin of thalassemia patients: ered the main reason of the redox imbalance. These measurements have r been matched with a non-invasive, and yet e unexplored in clinical practice, evaluation of body’s oxidative stress through measurement m of antioxidant carotenoids in skin, by a specm troscopic method based on Raman technology (RRS).
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