Abstract
Gastric cancer is usually diagnosed at late stage and has a high mortality rate, whereas early detection of gastric cancer could bring a better prognosis. Conventional gastric cancer diagnostic methods suffer from long diagnostic times, severe trauma, and a high rate of misdiagnosis and rely heavily on doctors’ subjective experience. Raman spectroscopy is a label-free molecular vibrational spectroscopy technique that identifies the molecular fingerprint of various samples based on the inelastic scattering of monochromatic light. Because of its advantages of non-destructive, rapid, and accurate detection, Raman spectroscopy has been widely studied for benign and malignant tumor differentiation, tumor subtype classification, and section pathology diagnosis. This paper reviews the applications of Raman spectroscopy for the in vivo and in vitro diagnosis of gastric cancer, methodology related to the spectroscopy data analysis, and presents the limitations of the technique.
Highlights
Gastric cancer is the fifth most commonly diagnosed cancer worldwide and the third most common cause of cancer-related death because it is usually advanced at the time of diagnosis (Bray et al, 2018)
This paper focuses on the field of gastric cancer based on a review of 35 articles found using the keyword “gastric cancer Raman” and reviews the research progress of Raman spectroscopy in the early diagnosis of gastric cancer
Raman spectroscopy is a new method for label-free gastric cancer diagnosis that can identify the differences in chemical composition between different types of gastric cancer samples
Summary
Gastric cancer is the fifth most commonly diagnosed cancer worldwide and the third most common cause of cancer-related death because it is usually advanced at the time of diagnosis (Bray et al, 2018). Raman spectroscopy is an objective and sensitive optical diagnostic technique for detecting gastric cancer that is non-invasive to the body, allows for real-time diagnosis, and is simple to use (Ouyang et al, 2015). The use of fiber optic Raman combined with endoscopy in the diagnosis of gastric cancer allows the acquisition of real-time images of the tumor, and simultaneous Raman spectral data acquisition for non-destructive and flexible detection of the digestive tract (Duraipandian et al, 2012; Wang et al, 2015). Numerous studies have shown that the use of endoscopic Raman probes can diagnose gastric dysplasia (Huang et al, 2009; Huang et al, 2010a), benign and malignant
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